Pathophysiology Research


Patient-specific computational tools can be used to further understand hemodynamic changes under various physiologic blood flow conditions and uniquely investigate potential sources of morbidity in a manner not possible with current diagnostic modalities. For example, in-silico models enable the study of the effect of exercise without the need to image the subject under actual exercise conditions. In-silico modeling is also useful in studying abnormal biomechanical stimuli present in many cardiovascular conditions, including abdominal aortic aneurysms (AAA). The figure below shows differences in time average wall shear stress and oscillatory shear index in 8 AAA patients under resting and exercising conditions.